With a new technique developed, the DNA and RNA in the cell can be visualized. This technique is believed to be very helpful in understanding diseases.
A new study shows that the DNA microscopy technique, which allows us to see the DNA and RNA in living cells, has been perfected in about 6 years.
You can comment on the nebula for the above image. In fact, what visual is much more amazing. Visually, a cell's shining parts show the location of the DNA and RNA inside the cell.
Joshua Weinstein, chief researcher in biology and medicine at MIT, a PhD at the Broad Institute, said: “DNA microscopy is a completely new technique for collecting both 3-D and genetic information from a sample and visualizing cells”.
This technique allows scientists to see the exact sequence of nucleotides (the genetic code in 2 strands of DNA and the single strand of RNA). Weinsta of: “This technique will allow us to see how their genetically unique structures, such as cancer, the immune system, or intestinal cells, interact with each other, and how cells evolve into multicellular forms.” said.
In recent years, scientists have developed tens of thousands of tools for collecting molecular data from tissue samples, but combining these data with 3D data to see where the genetic material in the cell is located and how it was ordered was very costly and required complex machines.
The new technique developed will make the process much easier, the researchers said. This technique takes advantage of small tags consisting of customized DNA sequences, each 30 nucleotides in length. These tags bind to each DNA and RNA in the cell, and then the tags are copied until there are tens of thousands in the cell. As these copies interact and merge with each other, they generate different DNA tags.
Researchers say that the interaction between the generated DNA tags is the main reason why the technique works. Once scientists have collected and sequenced the labeled molecules, a computer algorithm can locate the original locations of the labels in the cell and reveal a colorized picture of the sample.
Research can help scientists better understand different diseases. For example, research can map the location of cancer cells in a sample. These synthetic labels in DNA can also help locate receptors and molecules in tumor cells. Weinstein, “We used DNA mathematically in a similar way to photons in light microscopy” says and adds: “This technique will enable us to visualize biology cellularly and to see it in a very different way from that seen by the human eye.”