During 1999-2016, more than 200 deaths occurred in the United States due to high doses of pain relievers. Scientists who have long struggled to solve this problem and develop an addictive drug have taken this step closer.
According to research published by a group of researchers in the journal Science Translational Medicine, a new, very effective and no pain reliever has been developed. The AT-121 named drug, as usual painkillers do, the brain is numbing the relevant part controlling the pain;
"It's exciting to see that two things work together."
"It's exciting to see two things working together." Dr. Mei-Chuan Ko, Professor of Pharmacology at Wake Forest University, said that the new study was successful in experiments on Rhesus monkeys (Macaca mulatta).
A drug has been developed to provide the body's cancer cells diet
Mei-Chuan Ko said that traditional painkillers are influencing Mu receptors in the brain and spinal cord, triggering a molecular cascade that allows the cells to feel pain once activated once these receptors are activated. "It's not very healthy, because it affects other proteins in the body," he says. "Applying medicines such as morphine is not as good as it affects other proteins in the body."
The drug tested on monkeys is 100 times more effective than the morphine on pain relief. Monkeys were able to hold their tails in water at 50 degrees Celsius for several minutes while the drug was in effect, requiring several more doses to reach the same morph.
Ko's team continues to work to determine the best formulation and dose of the drug before people work on it.